Takara Bio Europe Rolls Launched Shasta™ Single-Cell System for Next-Generation Large-Scale NGS Profiling
Takara Bio Europe has introduced the ShastaTM Single-Cell System at the 2024 Human Cell Atlas General Meeting, a high-throughput NGS solution for large-scale biomarker discovery in oncology research.
The Shasta™ Single-Cell System combination of highly validated chemistries with intuitive bioinformatics tools will enable researchers to extract richer and more comprehensive genomic and transcriptomic data from an unprecedented number of cells while saving both time and expenses.
Redefining Throughput in Single-Cell NGS
The Shasta™ Single-Cell System raises the bar on throughput in NGS profiling. Its Shasta Whole-Genome Amplification (WGA) Kit significantly extends processing capability–allowing up to 1,500 cells analyzed per run–far exceeding the limits of the most current technologies, which typically process as many as 384 single cells. This advancement simultaneously scales up whole-genome amplification and allows for the direct detection of CNVs within single cells through shallow sequencing. Another great feature of the Shasta Total RNA-Seq Kit is full gene body coverage for up to 100,000 cells per run, meaning it is the first high-throughput single-cell RNA profiling kit that detects diverse RNA types, including non-polyadenylated lncRNAs, which existing droplet-based methods have been missing from covering. It is quite a giant step forward from traditional plate-based full-length RNA sequencing and high-throughput mRNA sequencing techniques.
Shasta role in Transforming Genomic Research.
The Shasta™ Single-Cell System is a complete advanced solution designed to advance genomic discovery. It combines whole genome amplification and RNA sequencing in a single workflow to simplify the investigation of genetic events at very high resolution. It offers full capability in oncology, gene regulation, and cellular pathway studies with splicing variant analysis, gene fusion detection, and structural alteration observation. This has opened the door to a supporting platform for an all-inclusive discovery of biomarkers, with fewer barriers of time and cost associated with large-scale single-cell studies.
Shasta’s Impact on the Future Biomarker Discovery
The Shasta system is working towards accelerating translational genomics and clinical research by offering a platform that not only pushes the envelope of single-cell analysis but has the capability to analyze thousands of single cells in one go. With high-throughput capabilities and sophisticated data-analysis tools, it now allows researchers to probe even more deeply into complex biological phenomena and unravel unknown biomarkers. It thus marks a major step forward on the path to personalized medicine and novel strategies for treating disease.
The Shasta™ Single-Cell System is breakthrough technology that will address an important juncture in next-generation sequencing: capable of boosting throughput without compromising accuracy, it will totally change the single-cell game. With simplicity offered in workflows and increased detection capabilities, Takara Bio Europe has set a new benchmark for biomarker discovery and genomics research in the future.
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