BRaVa Browser

BRaVa Browser is a free, open-source web browser for gene-level rare coding-variant association results from the Biobank Rare Variant Analysis (BRaVa) consortium — a meta-analysis spanning roughly 1.2 million individuals across ten global biobanks. It is modelled on gnomAD and Genebass, and covers 44 traits.

Search runs over gene symbols, Ensembl IDs and traits. A gene page gives phenome-wide associations, a cross-ancestry forest plot showing effect size with 95% confidence intervals per ancestry alongside the meta-analysis and a heterogeneity p-value, and a sortable results table. A phenotype page renders a canvas Manhattan plot with a virtualised results table, and any gene links through to its forest plot. Results can be filtered by ancestry (cross-ancestry meta, or EUR, AFR, AMR, EAS, SAS and non-EUR), variant mask, minor allele frequency cutoff, and test — Burden, SKAT or SKAT-O.

Architecturally it is a static site with no server to maintain: a Polars ETL pipeline reduces roughly 8 GB of gzipped TSVs into compact per-gene and per-phenotype JSON held in object storage, and a React and TypeScript single-page app bundles only the small search indexes and fetches the rest on demand. The source is MIT-licensed.