Tools of the Trade

A curated directory of the software researchers actually use - from literature discovery and reference managers to electronic lab notebooks, analysis pipelines, imaging and the new generation of AI research tools. Every entry is written by hand, and every outbound link is checked.

  • 254 tools listed
  • 20 categories
  • 214 free or open source
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22 tools in Bioinformatics

AlphaFold 3

Biomolecular Structure Prediction

AnalysisBioinformaticsFREE FOR NON-COMMERCIAL USE

AlphaGenome

Regulatory Genome Prediction Model

AnalysisBioinformaticsFREE FOR NON-COMMERCIAL USE

AnnData

Annotated Data Structure for Single-Cell

AnalysisBioinformaticsFREE, OPEN SOURCE

Bioconductor

R Packages for Genomic Analysis

AnalysisBioinformaticsFREE, OPEN SOURCE

Biomni

General-Purpose Biomedical AI Agent

Biopython

Python Tools for Computational Biology

AnalysisBioinformaticsFREE, OPEN SOURCE

Boltz

Open Source Biomolecular Structure Prediction

AnalysisBioinformaticsFREE, OPEN SOURCE

BoltzGen

Generative Binder Design at Speed

AnalysisBioinformaticsFREE, OPEN SOURCE

Cell Ranger

10x Genomics Single-Cell Pipeline

Chai-1

Open Multimodal Structure Prediction

AnalysisBioinformaticsFREE FOR NON-COMMERCIAL USE

ColabFold

AlphaFold in a Colab Notebook

AnalysisBioinformaticsFREE, OPEN SOURCE

CryoSPARC

Cryo-EM Structure Determination

AnalysisBioinformaticsFREE FOR ACADEMIC USE

Built something researchers should know about?

We add tools on reader suggestions, and we list open-source projects and one-person side projects on the same terms as funded platforms. Listing is free, there is no paid placement, and we write the entry ourselves after trying the tool.

Missing a tool?

Tell us what your lab runs on. Listing is free and we do not take payment for placement.

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How entries are chosen

  • It has to be alive. Links are verified, and tools that die or get acquired into irrelevance are retired rather than left to rot.
  • Researchers have to actually use it. Adoption in real labs matters more than a polished launch page.
  • Cost is stated plainly. Free, open source, freemium or paid - including when "free for academics" comes with conditions.
  • No paid placement. Nobody buys their way onto this list, and there are no affiliate links.
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What is in here

The directory covers the whole research workflow: planning and funding, literature discovery, reference management, lab notebooks and inventory, analysis and computation, figures and visualisation, writing, publishing, and data sharing. Alongside the long-established tools you would expect, it tracks the AI workbenches and foundation models now reshaping how computational research gets done.